What is Avana 100 Mg ?
Avana 100 Mg tablets contain avanafil, a phosphodiesterase type 5 inhibitor, that is used to help men with erectile dysfunction (impotence), to achieve and maintain an erection, when sexually aroused.
Avana 100 Mg is also available as Stendra 100 Mg. Avana tablets 100mg are used to treat erectile dysfunction (impotence) in men, which is inability to achieve or maintain a hard erect penis suitable for sexual activity, due to insufficient blood flow into the penis. Avana tablets 100mg relax the blood vessels in the penis increasing blood flow and causing an erection, which is the natural response to sexual stimulation. However, Avana tablets 100mg will only work if you are sexually aroused.
During sexual stimulation nitric oxide is released in the erectile tissue of the penis which activates the enzyme guanylate cyclase. This enzyme increases levels of a chemical called cyclic guanosine monophosphate (cGMP), which relaxes the blood vessels in the penis and allows blood to fill the spongy erectile tissues to cause an erection. Another enzyme called phosphodiesterase type 5 (PDE5) breaks down cGMP preventing blood flow into the penis, which causes loss of an erection. Avanafil in Avana tablets 100mg acts on the erectile tissue of the penis to inhibit the action of PDE5 and increase blood flow to cause an erection. This action of avanafil in Avana tablets 100mg resolves erectile dysfunction by allowing the natural process of sexual stimulation to activate the cGMP mechanism for achieving and maintaining an erection.
Avana 100 Mg Precautions
You should not use Avana tablets 100mg if you:
- are allergic to avanafil or any ingredients in Avana
- are taking any nitrate medication, such as nitroglycerin for angina, as it may lead to a severe drop in blood pressure
- have liver or kidney disease
- have a condition where sexual intercourse is inadvisable due to cardiovascular or heart problems or you have had a heart attack or stroke in the last 6 months
- have abnormally high or low blood pressure
- have an eye disease like non-arteritic anterior ischaemic optic neuropathy (NAION), which causes loss of vision, or if you have retinitis pigmentosa
- have conditions which may predispose to priapism (erections lasting 4 hours or more) such as anatomical deformation of the penis, sickle cell anaemia, multiple myeloma or leukaemia
- drink large amounts of alcohol or grapefruit juice
- are taking medication that may interact with Avana or may increase your risk for side-effects, antibiotics like erythromycin and rifampicin, verapamil or diltiazem (for high blood pressure), ritonavir or saquinavir for HIV, antifungals like itraconazole or ketaconazole, non-selective alpha-blockers like doxazosin for high blood pressure, tamsulosin and prazosin for enlarged prostate, nitrates such as glyceryl trinitrate for angina and other heart conditions.
The most common side effects of avanafil are:
- facial flushing (reddening),
- back pain,
- nasal congestion,
- dizziness, and
- upper respiratory tract infections.
- nausea, and
- flu-like symptoms
Avanafil also may cause low blood pressure, blurred vision and changes in color vision, and abnormal ejaculation. Avanafil may cause prolonged erections or priapism (painful erections lasting more than 6 hours). Patients should seek immediate medical help if they experience an erection lasting more than 4 hours.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
A product that may interact with this drug is: riociguat.
Avanafil can cause a serious drop in your blood pressure when used with nitrates, which can lead to dizziness, fainting, and rarely heart attack or stroke. Do not use avanafil with any of the following: certain drugs used to treat chest pain/angina (nitrates such as nitroglycerin, isosorbide), recreational drugs called “poppers” containing amyl or butyl nitrite.
If you are also taking an alpha blocker medication (such as doxazosin, tamsulosin) to treat an enlarged prostate/BPH or high blood pressure, your blood pressure may get too low which can lead to dizziness or fainting. Your doctor may start treatment with a lower dose of avanafil to minimize your risk of low blood pressure.
Other medications can affect the removal of avanafil from your body, which may affect how avanafil works. Examples include azole antifungals (such as itraconazole, ketoconazole), cobicistat, macrolide antibiotics (such as clarithromycin, erythromycin), HIV protease inhibitors (such as indinavir, ritonavir), hepatitis C virus protease inhibitors (such as boceprevir, telaprevir), nefazodone, ribociclib, rifampin, among others.
Do not take this medication with any other product that contains avanafil or other similar medications used to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil, vardenafil).